Potassium Carbonate → HCID 53251705, compound

Participants

Reaction Steps

To a suspension of 2-oxo-2-{[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]amino}ethyl acetate 1 (8.3 mg, 0.019 mmol) in MeOH (1 mL) at room temperature, under nitrogen, was added potassium carbonate (5.25 mg, 0.038 mmol). The mixture was stirred at room temperature for 18 hours. The mixture was filtered through celite and concentrated to dryness. The product was purified by column chromatography on silica gel (ethanol/ethyl acetatee) to afford 2-hydroxy-N-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]acetamide (2.3 mg, 30.7%) as a beige solid. APCI [M+H]+ m/z 396.0. 1H NMR (400 MHz, DMSO): δ 11.86 (s, 1H); 10.31 (s, 1H); 8.86 (d, J=4.9 Hz, 1H); 8.12 (s, 1H); 7.82 (s, 1H); 7.65 (d, J=8.0 Hz, 1H); 7.42-7.23 (m, 3H); 5.55 (t, J=6.3 Hz, 1H); 4.18 (d, J=6.0 Hz, 2H). rhSYK activity=+++

Provenance & Evidence