反应详情

To a solution of the ethyl 1-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]piperidine-4-carboxylate (457 mg, 1.26 mmol) in ethyl acetae (10 mL) and acetic acetic acid (1 mL) was added 10% palladium on carbon (135 mg, 0.126 mmol) and the mixture was placed under an atmosphere of H2 (balloon). The mixture was stirred for 3 hours was then filtered through celite. The filtrate was concentrated under reduced pressure. The resulting residue was purified by CombiFlash (20-60% ethyl acetate:hexanes) provided 250 mg (0.754 mmol, 60% yield) of ethyl 1-[4-(3-aminophenyl)-1,3-thiazol-2-yl]piperidine-4-carboxylate.

1. filtrationwas then filtered through celite
2. concentrationThe filtrate was concentrated under reduced pressure
3. customThe resulting residue was purified by CombiFlash (20-60% ethyl acetate:hexanes)