HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Iodine → 3-(cyclobutylmethyl)-4,4,6,6-tetramethyl-4,6-dihydrofuro[3,4-d]thiazol-2(3H)-imine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Iodine | HCID 807 | — |
| Edukt | 2,2,5,5-Tetramethyltetrahydro-3-ketofuran | HCID 138511 | — |
| Edukt | Potassium thiocyanate | HCID 516872 | — |
| Edukt | 1-Cyclobutylmethanamine hydrochloride | HCID 21707944 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 3-(cyclobutylmethyl)-4,4,6,6-tetramethyl-4,6-dihydrofuro[3,4-d]thiazol-2(3H)-imine | HCID 66852127 | — |
Reaktionsschritte
Commercially available 2,2,5,5-tetramethyldihydrofuran-3(2H)-one (Aldrich), triethyl amine, cyclobutylmethanamine hydrochloride (prepared from cyclobutanecarbonitrile as described in WO 2005075464), potassium thiocyanate (Aldrich) and iodine (EMD chemicals) were processed using the method described in Example 17A to afford the title compound. MS (ESI+) m/z 267 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08735434B2 |
| Quelldatensatz | uspto-grants-2014_05 |
| ORD ID | ord-cad6d81726db497ea6dcaace7af79e6c |
| Quellennotiz | uspto-grants-2014_05 |