HCID 57437675, compound → HCID 57437676, compound

Participants

Reaction Steps

A solution of pyridin-4-yl(1-trityl-1H-imidazol-5-yl)methanone (500 mg, 1.19 mmol) in dichloromethane (25 mL) at room temperature was treated with benzyl magnesium bromide (0.595 mL, 1.78 mmol, 3M in ether) and allowed to react at room temperature and the reaction mixture was then stirred at room temperature for 16 hours. The mixture was quenched with water (20 mL) and a saturated solution of ammonium chloride (20 mL). The residue was isolated in a typical aqueous to give pyridin-4-yl(1-trityl-1H-imidazol-5-yl)methanol, (Intermediate 4) (526 mg, crude).

Provenance & Evidence