Ethanol → HCID 178521730, compound

Participants

Reaction Steps

To a mixture of trans-6-[3-(2-fluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-(3-ethoxycarbonyl-2-oxo-propyl)-cyclohexyl ester (189 mg) obtained in Example (42a) and ethanol (5 mL), hydrazine monohydrate (0.022 mL) was added at 0° C. During the reaction, hydrazine monohydrate was further added thereto, and the mixture was stirred until the reaction substrate was consumed. The reaction mixture was concentrated and purified by column chromatography (dichloromethane/methanol) to obtain a white solid. This white solid was vigorously stirred in isopropyl ether and collected by filtration to obtain the title compound (90 mg, 51%) as a white solid.

Provenance & Evidence