Hydroxyamine hydrochloride → HCID 178521731, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of trans-6-[3-(2-fluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-(3-ethoxycarbonyl-2-oxo-propyl)-cyclohexyl ester (127 mg) obtained in Example (42a) and ethanol (3 mL), hydroxylamine hydrochloride (164 mg) was added at room temperature in the same way as in Example (42b). The reaction mixture was heated at 80° C. for 12 hours and concentrated. The residue was purified by column chromatography (dichloromethane/ethyl acetate). The obtained solid was purified by PTLC (dichloromethane/ethyl acetate=1:1) to obtain the title compound (34 mg, 28%) as an orange solid.

Provenance & Evidence