Phenyl glycidyl ether → HCID 71260586, compound

HRID 1028317Notes

Reaction equation

HRID 1028317 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]1[CH:11]=[N:12][C:13]([CH3:15])=[CH:14][C:5]2=1.[O:16]([CH2:23][CH:24]1[CH2:26][O:25]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:26][CH:24]([OH:25])[CH2:23][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:6]1[CH:11]=[N:12][C:13]([CH3:15])=[CH:14][C:5]2=1

Participants

3

Reactant 2

HCID 31217Phenyl glycidyl etherHCID 71254050HCID 71254050, compound

Product 1

HCID 71260586HCID 71260586, compoundYield 78%

Procedure

Following Representative Procedure 1, the title compound 1-(6-bromo-3-methyl-9H-pyrido[3,4-b]indol-9-yl)-3-phenoxypropan-2-ol was prepared from 6-bromo-3-methyl-9H-pyrido[3,4-b]indole and phenoxymethyloxirane in 78% yield after a precipitation from isopropanol.

Workup

  1. customafter a precipitation from isopropanol

Sources & evidence

ORD record
ord-55717421047a4688a5619d4b877d7b1e
Source dataset
uspto-grants-2014_05
Patent number
US08735440B2

Reaction notes

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