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HRID1028410

反应详情

EQUATION

反应方程式

HRID 1028410 的结构方程式

REACTANTS

反应物

5
结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：Brc1ccc2[nH]ccc2c1
HCID24905

1H-Indole, 5-bromo-

C8H6BrN

结构：CN1CCC(=O)CC1
HCID74049

1-Methyl-4-piperidone

C6H11NO

结构：CN1CC=C(c2c[nH]c3ccc(Br)cc23)CC1
HCID14973208

5-Bromo-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

C14H15BrN2

结构：CC=CN[SH](=O)=O
HCID178458093

未命名化合物

PRODUCTS

生成物

1
结构：CNS(=O)(=O)CCc1ccc2[nH]cc(C3CCN(C)CC3)c2c1
HCID4440

Naratriptan

C17H25N3O2S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

In another process as described in US '841, if the reaction of 5-bromoindole with 1-methylpiperidin-4-one by means of KOH in methanol is carried out at reflux temperature the resulting product is 5-bromo-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole which is further condensed with N-methylvinylsulfonamide as described above to obtain naratriptan.

WORKUP

后处理

  1. temperatureat reflux temperature the resulting product