Hydrochloric Acid → Naratriptan Hydrochloride

Participants

Reaction Conditions

Reaction Steps

2-[3-(1-Methyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide (Naratriptan base) (100 g) was dissolved in methanol (1500 ml) under stifling for 30 minutes to obtain a clear solution. The reaction mass was cooled to 5-10° C. and 20% aqueous hydrochloric acid was added till the pH of the reaction mass was adjusted to 1.0. The temperature of the reaction mass was raised to 25° C. and filtered. The solid was dried in vacuum chamber at 50-55° C. to obtain the title compound. (Yield: 90 g, HPLC Purity: 99.69%)

Provenance & Evidence