Thionyl Chloride → HCID 86664521, compound

HRID 1028430Notes

Reaction equation

HRID 1028430 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([Cl:19])[C:17]=1[CH3:18])[C:12](O)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>C(#N)C>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([Cl:19])[C:17]=1[CH3:18])[C:12]([Cl:22])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 67217646HCID 67217646, compound

Product 1

HCID 86664521HCID 86664521, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

350 mg 3-benzyloxy-5-chloro-4-methyl-benzoic acid in 10 ml acetonitrile are combined with 0.60 ml thionylchloride and gently refluxed for 15 minutes. Then the reaction mixture is evaporated down and evaporated again with toluene. The acid chloride is further reacted without any further purification.

Workup

  1. temperaturegently refluxed for 15 minutes
  2. customThen the reaction mixture is evaporated down
  3. customevaporated again with toluene
  4. customThe acid chloride is further reacted without any further purification

Sources & evidence

ORD record
ord-11213441527341db8451f94f74cf363e
Source dataset
uspto-grants-2014_05
Patent number
US08735579B2

Reaction notes

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