Water → HCID 69170730, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-methoxyphenol (5.50 g, 44.3 mmol, 1.1 eq.), 2-bromothiazole (6.64 g, 40.0 mmol, 1.0 eq.), and K2CO3 (6.60 g, 47.8 mmol, 1.2 eq.) in dimethyl sulfoxide (40 mL) was heated to 160° C. for 5 hours. The reaction mixture was poured into water and extracted with ether. The ether layer washed with 10% NaOH, then brine, dried over MgSO4, filtered and concentrated. The residue was purified on silica gel eluting with ethyl acetate:hexane (0-20%) to give the title compound (6.03 g, 73%),

Provenance & Evidence