反应详情

Diethyl 2-propyl-1H-imidazol-4,5-dicarboxylate hydrochloride (50.0 g) obtained in Example 11a and sodium chloride (50.0 g) were dissolved in water (500 ml), and 5N aqueous sodium hydroxide solution (30 ml) was added to this solution, followed by stirring for 1 hour under ice cooling. The precipitated crystals were collected by filtration, and subsequently dried under reduced pressure to afford the title compound (40.7 g) as white crystals. Each spectral data of the obtained compound coincided with that of the compound in Example 2.

1. filtrationThe precipitated crystals were collected by filtration
2. customsubsequently dried under reduced pressure