3,5-Bis(trifluoromethyl)benzyl bromide → 3-[3,5-Bis(trifluoromethyl)benzyl]-5-[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]-1,3-oxazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	3,5-Bis(trifluoromethyl)benzyl bromide	HCID 122573	—
Reactant	5-[5'-Isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]-1,3-oxazolidin-2-one	HCID 59135182	—
Product	3-[3,5-Bis(trifluoromethyl)benzyl]-5-[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]-1,3-oxazolidin-2-one	HCID 11721382	—

Reaction Steps

Following the procedure described in EXAMPLE 50, 44 mg of 5-[5′-isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]-1,3-oxazolidin-2-one, enantiomer B, and 43 mg of 3,5-bis(trifluoromethyl)benzyl bromide gave the title compound. Analytical HPLC on Chiralpak AS 4.6×250 mm, eluting with 5% isopropanol in heptane at 0.5 mL/min: tR=11.0 min

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08735435B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-d8d7f36c67814864bb0ce11dea3d6412
Source note	uspto-grants-2014_05