2-(2-Fluoro-3,4-dimethoxyphenyl)propan-2-ol → HCID 66716980, compound

Participants

Reaction Steps

A suspension of 10% palladium on carbon (69.8 mg) in a solution of 2-(2-fluoro-3,4-dimethoxyphenyl)propan-2-ol (698 mg, 3.26 mmol) in 5N HCl (0.7 mL) and EtOH (5.6 mL) was stirred at room temperature under H2 (15 psi) overnight. The mixture was filtered through a plug of Celite and washed with EtOAc (˜75 mL). The filtrate was washed with 50% saturated brine (10 mL), dried (MgSO4) and concentrated in vacuo to afford 2-fluoro-1-isopropyl-3,4-dimethoxybenzene. 1H NMR (500 MHz, CDCl3) δ 6.86 (t, J=8.3 Hz, 1H), 6.63 (dd, J=8.7, 1.5 Hz, 1H), 3.89 (s, 3H), 3.84 (s, 3H), 3.19-3.11 (m, 1H), 1.22 (d, J=6.8 Hz, 6H).

Provenance & Evidence