Ethyl isocyanate → HCID 11612890, compound

HRID 1028720Notes

Reaction equation

HRID 1028720 reaction equation
[NH2:1][C:2]1[C:3]2[N:4]([C:8]([CH:27]3[CH2:32][CH2:31][N:30]([C:33](=[O:35])C)[CH2:29][CH2:28]3)=[N:9][C:10]=2[C:11]2[CH:20]=[C:19]3[C:14]([CH:15]=[CH:16][C:17]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[N:18]3)=[CH:13][CH:12]=2)[CH:5]=[CH:6][N:7]=1.[CH2:36]([N:38]=C=O)[CH3:37]>>[NH2:1][C:2]1[C:3]2[N:4]([C:8]([CH:27]3[CH2:28][CH2:29][N:30]([C:33]([NH:38][CH2:36][CH3:37])=[O:35])[CH2:31][CH2:32]3)=[N:9][C:10]=2[C:11]2[CH:20]=[C:19]3[C:14]([CH:15]=[CH:16][C:17]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[N:18]3)=[CH:13][CH:12]=2)[CH:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 8022Ethyl isocyanateHCID 11677004HCID 11677004, compound

Product 1

HCID 11612890HCID 11612890, compound

Procedure

4-(8-Amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-N-ethylpiperidine-1-carboxamide was synthesized using the same procedure as 1-{4-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]piperidin-1-yl}ethanone except ethylisocyanate was used instead of acetic anhydride; yellow powder; MS (ES+): m/z 492.10 (70) [MH+], 493.11 (45) [MH+2], 211.41 (100) [MH-280]; HPLC: tR=2.08 min (polar-5 min/openlynx).

Workup

  1. customHPLC: tR=2.08 min (polar-5 min/openlynx)

Sources & evidence

ORD record
ord-1370395cc3194b0eae6902d695d74d84
Source dataset
uspto-grants-2014_05
Patent number
US08735405B2

Reaction notes

Loading…