Octanoyl chloride → 1-(4-(3-Nitropropyl)phenyl)octan-1-one

HRID 1028879Notes

Reaction equation

[N+:1]([CH2:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([O-:3])=[O:2].[C:13](Cl)(=[O:21])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>>[N+:1]([CH2:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:21])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:9][CH:8]=1)([O-:3])=[O:2]

Participants

Reactant 2

HCID 8124Octanoyl chloride

HCID 5623331-Nitro-3-phenylpropane

Product 1

HCID 569671461-(4-(3-Nitropropyl)phenyl)octan-1-one

Procedure

The title compound was prepared from 3-nitropropylbenzene (16) and octanoyl chloride, according to example 2, affording compound (17) with 73% yield, which was used at the next step without additional purification.

Sources & evidence

ORD record: ord-6531ceccde614649831d3d15c1f2aa89
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08735627B2

Reaction notes

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