HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-(4-(4-Hydroxy-3-(hydroxymethyl)-3-nitrobutyl)phenyl)octan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 1-(4-(3-Nitropropyl)phenyl)octan-1-one | HCID 56967146 | — |
| Product | 1-(4-(4-Hydroxy-3-(hydroxymethyl)-3-nitrobutyl)phenyl)octan-1-one | HCID 86693812 | — |
Reaction Steps
Compound (18) was prepared by Henry addition of formaldehyde (37% aqueous solution) to 1-(4-(3-nitropropyl)phenyl)octan-1-one (17) in ethanol, in the presence of strongly basic anion exchange resin Amberlite IRA-401(0H-), according to the procedure described by Astle and Abbot [J. Org. Chem. 21, 1228 (1956)]. The yield of the desired product was 65%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735627B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-218961929bac4e81ab10242270e043c7 |
| Source note | uspto-grants-2014_05 |