Hydrochloric Acid → HCID 68560150, compound

Participants

Reaction Steps

A mixture of (E)-2,4,6-Trimethoxystyryl-3-[(p-Toluenesulfonyl)oxy]-4-methoxy-benzyl sulfones 26, (5.0 g, 9.1 mmol), 50 mL (20%) sodium hydroxide solution and methanol (50 mL) were taken in a round bottomed flask and refluxed until the reaction mixture is clear without any turbidity (3-4 h). The progress of the reaction was monitored by TLC. The reaction mixture was cooled to room temperature and neutralized with cold dilute HCl solution. The precipitate separated after neutralization was filtered, washed with water and dried to get the crude product which on recrystallization from 2-propanol resulted analytically pure sample 6aa. Yield: 95%; white solid mp 124-127° C.

Provenance & Evidence