HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1028933Generated: October 27, 2026
4-Methoxybenzylamine → 6-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine
https://huagongshe.com/reaction/1028933
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Reactant | 6-Bromo-2-chloro-3-iodoquinoline | HCID 86676837 | — |
| Product | 6-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine | HCID 67345652 | — |
Reaction Steps
6-Bromo-2-chloro-3-iodoquinoline (1.0 g, 2.7 mmol) and neat 4-methoxybenzylamine (3.6 mL, 27.1 mmol) was combined in a microwave vial and heated in a microwave at 130° C. for 15 min. The reaction mixture was purified by silica flash chromatography (0-30% EtOAc/Hex) to give 6-bromo-3-iodo-N-(4-methoxybenzyl)quinolin-2-amine as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08735384B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-eced43b58d884e6baa1a3d853801dd21 |
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| Source note | uspto-grants-2014_05 |
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