Sodium Hydroxide → HCID 67325374, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 6-(2-(imino(2-methoxyphenyl)methyl)-6-methylphenyl)-3-morpholinoquinolin-2-amine (0.022 g, 0.049 mmol) in 5N aq. HCl (2 mL) was heated to 100° C. in a sealed tube for 16 h, then allowed to cool to 50° C. and heated for another 70 h at that temperature. The mixture was neutralized with 10N NaOH and filtered. The precipitate was redissolved in MeOH and purified by reverse-phase HPLC (10-90% acetonitrile/H2O, TFA modifier). A single fraction was treated with NH4OH and the acetonitrile was removed in vacuo. The resulting suspension was filtered and air-dried to afford (2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(2-methoxyphenyl)methanone. MS (ESI, pos. ion) m/z: 454 (M+1).

Provenance & Evidence