反应详情

2-Bromophenylhydrazine hydrochloride (1.00 g, 4.47 mmol) was added to a solution of 2-(hydroxymethylene)cyclohexanone (0.564 g, 4.47 mmol) in ethanol (20 mL) and the resulting solution was refluxed 3 h before being concentrated. The crude material was taken up in DCM and washed with saturated ammonium chloride, 1N NaOH, saturated sodium chloride, and dried over sodium sulfate. The solution was filtered and concentrated in vacuo to give 1-(2-bromophenyl)-4,5,6,7-tetrahydro-1H-indazole.

1. temperaturethe resulting solution was refluxed 3 h
2. concentrationbefore being concentrated
3. washwashed with saturated ammonium chloride, 1N NaOH, saturated sodium chloride
4. dry with materialdried over sodium sulfate
5. filtrationThe solution was filtered
6. concentrationconcentrated in vacuo