Hydrochloric Acid → HCID 71253315, compound

Participants

Reaction Steps

A solution of methyl 2-(2-amino-3-morpholinoquinolin-6-yl)-3-(3,3-dimethylbutyl)benzoate (520 mg, 1.162 mmol) in MeOH (20 mL) and 5N NaOH (0.929 mL, 4.65 mmol) was heated to 80° C. for 7 h. The solution was cooled to RT and acidified with 5N HCl to pH of ˜4. The solution was concentrated under reduced pressure. The residue was dissolved in MeOH and filtered. The filtrate was concentrated under reduced pressure to yield 2-(2-amino-3-morpholinoquinolin-6-yl)-3-(3,3-dimethylbutyl)benzoic acid hydrochloride as a brown solid which was used without further purification.

Provenance & Evidence