Potassium Carbonate → HCID 58168343, compound

Participants

Reaction Conditions

Reaction Steps

2-Amino-3-bromopyridine (87 mg, 0.50 mmol), 5-fluoro-2-methoxycarbonylphenylboronic acid (149 mg, 0.75 mmol), palladium(II) acetate (5 mg, 0.02 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (16 mg, 0.04 mmol), and potassium carbonate (207 mg, 1.50 mmol) were dissolved in dioxane/H2O (1.65 mL, 10/1, v/v), and stirred overnight at 100° C. The reaction mixture was concentrated, suspended in EtOAc/H2O, and filtered. The precipitate was washed with EtOAc/H2O, and dried under vacuum to provide 3 (35 mg, 33% yield) as a solid. LC-MS (M+H=215, obsd.=215). 1H NMR (400 MHz, d6-DMSO): δ 12.12 (s, 1H), 8.84 (d, 1H), 8.53 (d, 1H), 8.43 (d, 1H), 8.38 (dd, 1H), 7.53 (t, 1H), 7.33 (dd, 1H).

Provenance & Evidence