Isopropanol → HCID 58167981, compound

Participants

Reaction Conditions

Reaction Steps

6,9-Dichloro-benzo[c][1,8]naphthyridine (20 mg, 0.08 mmol), and 3-chloro-4-fluoroaniline (24 mg, 0.16 mmol) were suspended in isopropanol (2 mL) and stirred overnight at 120° C. The reaction solution was cooled to room temperature, and the resulting precipitate was filtered, washed with isopropanol, and dried under vacuum to provide 57 (18 mg, 63% yield) as a yellow solid. LC-MS (M+H=358, obsd.=358). 1H NMR (400 MHz, d6-DMSO): δ 10.75 (s, 1H), 9.63 (dd, 1H), 9.07 (d, 1H), 8.99 (d, 1H), 8.86 (dd, 1H), 8.33 (dd, 1H), 8.09 (dd, 1H), 8.04 (m, 1H), 7.80 (dd, 1H), 7.52 (t, 1H).

Provenance & Evidence