3-Chlorophenol → HCID 58168186, compound

Participants

Reaction Conditions

Reaction Steps

9-Fluoro-5H-benzo[c][1,8]naphthyridin-6-one (40 mg, 0.19 mmol), 3-chlorophenol (72 mg, 0.56 mmol), and potassium carbonate (129 mg, 0.93 mmol) were suspended in DMF (1.5 mL), and stirred for 20 minutes at 180° C. in the microwave. The reaction mixture was quenched with H2O. The resulting precipitate was filtered, washed with H2O, and dried under vacuum to provide 73 (50 mg, 83% yield) as a tan solid. LC-MS (M+H=323, obsd.=323). 1H NMR (400 MHz, d6-DMSO): δ 12.05 (s, 1H), 8.78 (dd, 1H), 8.51 (dd, 1H), 8.35 (d, 1H), 8.19 (d, 1H), 7.49 (t, 1H), 7.29 (m, 4H), 7.12 (dd, 1H).

Provenance & Evidence