P-Anisidine → HCID 58167987, compound

Participants

Reaction Conditions

Reaction Steps

2-Chloro-5H-benzo[c][1,8]naphthyridin-6-one (30 mg, 0.13 mmol), 4-methoxy aniline (32 mg, 0.26 mmol), palladium(II) acetate (2 mg, 0.01 mmol), 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (6 mg, 0.02 mmol), and sodium tert-butoxide (38 mg, 0.39 mmol) were suspended in dioxane (2 mL), and stirred overnight at 100° C. The reaction mixture was diluted with MeOH, filtered, and purified via prep-LC-MS to provide 87 (15 mg, 36% yield) as a solid. LC-MS (M+H=318, obsd.=318). 1H NMR (400 MHz, d6-DMSO): δ 11.86 (s, 1H), 8.33 (dd, 2H), 8.22 (m, 2H), 7.88 (dt, 1H), 7.68 (m, 1H), 7.11 (d, 2H), 6.91 (d, 2H), 3.73 (s, 3H).

Provenance & Evidence