Potassium Carbonate → HCID 58168016, compound

Participants

Reaction Conditions

Reaction Steps

9-Fluoro-5H-benzo[c][1,8]naphthyridin-6-one (40 mg, 0.19 mmol), 3-bromobenzyl alcohol (105 mg, 0.56 mmol), and potassium carbonate (129 mg, 0.93 mmol) were suspended in DMF (1 mL), and stirred for 20 minutes at 150° C. in the microwave. The reaction mixture was diluted with MeOH, filtered, and purified via prep-LC-MS to provide 90 (2 mg, 3% yield) as a solid. LC-MS (M+H=381, obsd.=381). 1H NMR (400 MHz, d6-DMSO): δ 11.88 (s, 1H), 8.88 (dd, 1H), 8.50 (dd, 1H), 8.26 (d, 1H), 8.10 (d, 1H), 7.77 (m, 1H), 7.56 (m, 2H), 7.38 (m, 3H), 5.38 (s, 2H).

Provenance & Evidence