Potassium Carbonate → HCID 58168329, compound

Participants

Reaction Conditions

Reaction Steps

9-Fluoro-5H-benzo[c][1,8]naphthyridin-6-one (40 mg, 0.19 mmol), 3-bromophenol (97 mg, 0.56 mmol), and potassium carbonate (129 mg, 0.93 mmol) were suspended in dimethylacetamide (2 mL), and stirred for 30 minutes at 200° C. in the microwave. The reaction mixture was quenched with H2O. The resulting precipitate was filtered, washed with H2O, and dried under vacuum to provide 93 (2 mg, 3% yield) as a solid. LC-MS (M+H=367, obsd.=367). 1H NMR (400 MHz, d6-DMSO): δ 12.01 (s, 1H), 8.78 (d, 1H), 8.52 (d, 1H), 8.35 (d, 1H), 8.22 (d, 1H), 7.43 (m, 3H), 7.29 (m, 2H), 7.18 (m, 1H).

Provenance & Evidence