4-Chlorophenylboronic acid → HCID 58168171, compound

HRID 1029123Notes

Reaction equation

HRID 1029123 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168171HCID 58168171, compoundYield 9%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 153 using Compound 83 (50 mg, 0.22 mmol) and 4-chlorophenylboronic acid (44 mg, 0.33 mmol) to provide 154 (6 mg, 9% yield) as a white solid. LC-MS (M+H=307, obsd.=307).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-c97a81dc82864e15b154941842d513c8
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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