HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethynyl-2-methoxybenzene → 1-(2-Methoxy-phenylethynyl)-5H-benzo[c][1,8]naphthyridin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethynyl-2-methoxybenzene | HCID 582912 | — |
| Reactant | 1-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one | HCID 58168008 | — |
| Product | 1-(2-Methoxy-phenylethynyl)-5H-benzo[c][1,8]naphthyridin-6-one | HCID 58168333 | 72% |
Reaction Steps
The title compound was synthesized according to the procedure described for the preparation of Example 160 using Compound 83 (100 mg, 0.43 mmol) and 1-ethynyl-2-methoxy-benzene (86 mg, 0.65 mmol) to provide 164 (101 mg, 71% yield) as a white solid. LC-MS (M+H=327, obsd.=327).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-dcc63f6d3b1c4a2cac74848ec5bc0868 |
| Source note | uspto-grants-2014_05 |