HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Morpholin-4-ylsulphonyl)benzeneboronic acid → 1-[4-(Morpholine-4-sulfonyl)-phenyl]-5H-benzo[c][1,8]naphthyridin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Morpholin-4-ylsulphonyl)benzeneboronic acid | HCID 44119546 | — |
| Reactant | 1-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one | HCID 58168008 | — |
| Product | 1-[4-(Morpholine-4-sulfonyl)-phenyl]-5H-benzo[c][1,8]naphthyridin-6-one | HCID 58167997 | 80% |
Reaction Steps
The title compound was synthesized according to the procedure described for the preparation of Example 171 using Compound 83 (100 mg, 0.43 mmol) and 4-(4-boronobenzenesulfonyl)morpholine (235 mg, 0.87 mmol) to provide 176 (145 mg, 79% yield) as a grey solid. LC-MS (M+H=422, obsd.=422).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-f6d5ba3001354120b1f4f5769e46446f |
| Source note | uspto-grants-2014_05 |