HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Aminosulphonyl)benzeneboronic acid → 4-(6-Oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Aminosulphonyl)benzeneboronic acid | HCID 22391977 | — |
| Reactant | 1-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one | HCID 58168008 | — |
| Product | 4-(6-Oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yl)-benzenesulfonamide | HCID 58168180 | 2% |
Reaction Steps
The title compound was synthesized according to the procedure described for the preparation of Example 171 using Compound 83 (100 mg, 0.43 mmol) and 4-(aminosulphonyl)benzeneboronic acid (174 mg, 0.87 mmol) to provide 177 (2 mg, 2% yield) as a grey solid. LC-MS (M+H=352, obsd.=352).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-436c2cbb1df4453dbd1f9818c87afa0b |
| Source note | uspto-grants-2014_05 |