HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dichloro-nicotinoyl chloride → 2,5-Dichloro-N-[3-fluoro-4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dichloro-nicotinoyl chloride | HCID 2799996 | — |
| Reactant | 1-(4-Amino-2-fluoro-phenoxy)-5H-benzo[c][1,8]naphthyridin-6-one | HCID 58168345 | — |
| Product | 2,5-Dichloro-N-[3-fluoro-4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-nicotinamide | HCID 58167983 | 45% |
Reaction Steps
The title compound was synthesized according to the procedure described for the preparation of Example 180 using Compound 182 (50 mg, 0.16 mmol) and 2,5-dichloro-nicotinoyl chloride (36 mg, 0.17 mmol) to provide 183 (35 mg, 45% yield) as a dark solid. LC-MS (M+H=496, obsd.=496).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-a2713a867d404be3af43d0f30477a00b |
| Source note | uspto-grants-2014_05 |