1-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid → HCID 58168182, compound

HRID 1029151Notes

Reaction equation

HRID 1029151 reaction equation
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]([O:6][C:7]2[CH:16]=[CH:15][N:14]=[C:13]3[C:8]=2[C:9]2[CH:21]=[CH:20][CH:19]=[CH:18][C:10]=2[C:11](=[O:17])[NH:12]3)=[CH:4][C:3]=1[F:24].[F:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH:37]=[CH:36][CH:35]=[C:34]([C:38](O)=[O:39])[C:33]2=[O:41])=[CH:28][CH:27]=1>>[F:24][C:3]1[CH:4]=[C:5]([O:6][C:7]2[CH:16]=[CH:15][N:14]=[C:13]3[C:8]=2[C:9]2[CH:21]=[CH:20][CH:19]=[CH:18][C:10]=2[C:11](=[O:17])[NH:12]3)[CH:22]=[CH:23][C:2]=1[NH:1][C:38]([C:34]1[C:33](=[O:41])[N:32]([C:29]2[CH:28]=[CH:27][C:26]([F:25])=[CH:31][CH:30]=2)[CH:37]=[CH:36][CH:35]=1)=[O:39]

Participants

3

Reactant 2

HCID 210815271-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acidHCID 58168352HCID 58168352, compound

Product 1

HCID 58168182HCID 58168182, compoundYield 78%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 181 using Compound 185 (50 mg, 0.16 mmol) and 1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (44 mg, 0.19 mmol) to provide 187 (65 mg, 78% yield) as a dark solid. LC-MS (M+H=537, obsd.=537).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-1e957eb185cb470b8ac6e0c35d2f7f4d
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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