3-Fluoroaniline → HCID 58168125, compound

HRID 1029154Notes

Reaction equation

HRID 1029154 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[F:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>>[F:17][C:18]1[CH:19]=[C:20]([NH:21][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 97423-FluoroanilineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168125HCID 58168125, compoundYield 65.5%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 3-fluoroaniline (96 mg, 0.87 mmol) to provide 190 (86 mg, 65% yield) as a white solid. LC-MS (M+H=306, obsd.=306).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-265566a07cda412089e4ed2ef2055b3b
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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