3-Methoxyaniline → HCID 58167947, compound

HRID 1029157Notes

Reaction equation

HRID 1029157 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][CH:25]=1)[NH2:22]>>[CH3:17][O:18][C:19]1[CH:20]=[C:21]([NH:22][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 108243-MethoxyanilineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58167947HCID 58167947, compoundYield 78.4%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 3-methoxyaniline (107 mg, 0.87 mmol) to provide 193 (107 mg, 78% yield) as a white solid. LC-MS (M+H=318, obsd.=318).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-76c347361b4548dd813312ec6d3d1058
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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