Diisopropylethylamine → HCID 68403216, compound

Participants

Reaction Conditions

Reaction Steps

Compound 179 (50 mg, 0.14 mmol), 1-isocyanato-4-isopropyl-benzene (34 mg, 0.21 mmol), and DIEA (0.07 mL, 0.42 mmol) were suspended in dioxane (2 mL), and stirred overnight at 80° C. The reaction mixture was quenched with 1M HCl, and diluted with EtOAc. The mixture was filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was purified via Biotage eluting with a gradient of 75 to 100 EtOAc in hexane to provide 197 (40 mg, 64% yield) as a yellow solid. LC-MS (M+H=442, obsd.=442).

Provenance & Evidence