2,4-Dichloro-5-methoxyaniline → HCID 58167985, compound

HRID 1029165Notes

Reaction equation

HRID 1029165 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:17][C:18]1[CH:24]=[C:23]([Cl:25])[C:22]([O:26][CH3:27])=[CH:21][C:19]=1[NH2:20]>>[Cl:17][C:18]1[CH:24]=[C:23]([Cl:25])[C:22]([O:26][CH3:27])=[CH:21][C:19]=1[NH:20][C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2

Participants

3

Reactant 2

HCID 14766362,4-Dichloro-5-methoxyanilineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58167985HCID 58167985, compoundYield 56%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 2,4-di-chloro-5-methoxyaniline (125 mg, 0.65 mmol) to provide 201 (77 mg, 56% yield) as a white solid. LC-MS (M+H=386, obsd.=386).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-600399981c0b4dbeb4a50b4cad0b3999
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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