5-Chloro-2-fluoroaniline → HCID 58168110, compound

HRID 1029169Notes

Reaction equation

HRID 1029169 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([F:25])=[C:22]([CH:24]=1)[NH2:23]>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([F:25])=[C:22]([NH:23][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)[CH:24]=1

Participants

3

Reactant 2

HCID 750155-Chloro-2-fluoroanilineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168110HCID 58168110, compoundYield 48%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 5-chloro-2-fluoroaniline (82 mg, 0.56 mmol) to provide 205 (70 mg, 48% yield) as a white solid. LC-MS (M+H=340, obsd.=340).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-e1345798cf324591994d58c954e82da0
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

Loading…