2-Chloro-6-fluoroaniline → HCID 58168287, compound

HRID 1029171Notes

Reaction equation

HRID 1029171 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:17][C:18]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:19]=1[NH2:20]>>[Cl:17][C:18]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:19]=1[NH:20][C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2

Participants

3

Reactant 2

HCID 27342052-Chloro-6-fluoroanilineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168287HCID 58168287, compoundYield 69.1%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 2-chloro-6-fluoroaniline (82 mg, 0.56 mmol) to provide 207 (101 mg, 69% yield) as a white solid. LC-MS (M+H=340, obsd.=340).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-f676576f441c40f29737c3645ea42e14
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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