6-Chloro-m-anisidine → HCID 58168286, compound

HRID 1029172Notes

Reaction equation

HRID 1029172 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:17][C:18]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:19]=1[NH2:20]>>[Cl:17][C:18]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:19]=1[NH:20][C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2

Participants

3

Reactant 2

HCID 754606-Chloro-m-anisidineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168286HCID 58168286, compoundYield 60.8%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 2-chloro-5-methoxyaniline (109 mg, 0.56 mmol) to provide 208 (92 mg, 60% yield) as a white solid. LC-MS (M+H=352, obsd.=352).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-2551270876ae4d3e894debaced37d236
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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