HRID1029174

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1c(C(=O)O)c(=O)n(-c2ccccc2)n1CC(C)(C)O

HCID53393430

未命名化合物

结构：Nc1ccc(Oc2ccnc3[nH]c(=O)c4ccccc4c23)c(F)c1

HCID58168345

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)c5ccccc5c34)c(F)c2)c(=O)n(-c2ccccc2)n1CC(C)(C)O

HCID58168353

未命名化合物

收率 33.7%

PROCEDURE

实验过程

The title compound was synthesized according to the procedure described for the preparation of Example 209 using Compound 182 (55 mg, 0.17 mmol) and 1-(2-hydroxy-2-methyl-propyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (60 mg, 0.21 mmol) to provide 210 (34 mg, 33% yield) as a white solid. LC-MS (M+H=594, obsd.=594).

WORKUP

后处理

customThe title compound was synthesized

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-36fbb6de4a5e442999b86818ce3501eb
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08735584B2
来源说明: uspto-grants-2014_05

反应 SMILES

[NH2:1][C:2]1[CH:23]=[CH:22][C:5]([O:6][C:7]2[CH:16]=[CH:15][N:14]=[C:13]3[C:8]=2[C:9]2[CH:21]=[CH:20][CH:19]=[CH:18][C:10]=2[C:11](=[O:17])[NH:12]3)=[C:4]([F:24])[CH:3]=1.[OH:25][C:26]([CH3:45])([CH3:44])[CH2:27][N:28]1[C:32]([CH3:33])=[C:31]([C:34](O)=[O:35])[C:30](=[O:37])[N:29]1[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>>[F:24][C:4]1[CH:3]=[C:2]([NH:1][C:34]([C:31]2[C:30](=[O:37])[N:29]([C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=3)[N:28]([CH2:27][C:26]([OH:25])([CH3:45])[CH3:44])[C:32]=2[CH3:33])=[O:35])[CH:23]=[CH:22][C:5]=1[O:6][C:7]1[CH:16]=[CH:15][N:14]=[C:13]2[C:8]=1[C:9]1[CH:21]=[CH:20][CH:19]=[CH:18][C:10]=1[C:11](=[O:17])[NH:12]2