4-Chloroaniline → HCID 44205290, compound

HRID 1029176Notes

Reaction equation

HRID 1029176 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:28]=[CH:27][C:25]([NH:26][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 78124-ChloroanilineHCID 58168153HCID 58168153, compound

Product 1

HCID 44205290HCID 44205290, compoundYield 30.8%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 212 using Compound 211 (50 mg, 0.17 mmol) and 4-chloroaniline (29 mg, 0.22 mmol) to provide 213 (20 mg, 30% yield) as a white solid. LC-MS (M+H=382, obsd.=382).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-483f8e35f5bd42e5afd5fad5e2759c59
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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