4-Fluoroaniline → HCID 58168152, compound

HRID 1029178Notes

Reaction equation

HRID 1029178 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[F:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:28]=[CH:27][C:25]([NH:26][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 58168153HCID 58168153, compound

Product 1

HCID 58168152HCID 58168152, compoundYield 3.2%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 212 using Compound 211 (50 mg, 0.17 mmol) and 4-fluoroaniline (25 mg, 0.22 mmol) to provide 215 (2 mg, 2% yield) as a white solid. LC-MS (M+H=366, obsd.=366).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-2630d21a94df40a3be68daab9f432c8f
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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