2-Fluoroaniline → HCID 44205291, compound

HRID 1029179Notes

Reaction equation

HRID 1029179 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[F:21][C:22]1[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=1[NH2:24]>>[F:21][C:22]1[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=1[NH:24][C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2

Participants

3

Reactant 2

HCID 95842-FluoroanilineHCID 58168153HCID 58168153, compound

Product 1

HCID 44205291HCID 44205291, compoundYield 3.2%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 212 using Compound 211 (50 mg, 0.17 mmol) and 2-fluoroaniline (25 mg, 0.22 mmol) to provide 216 (2 mg, 3% yield) as a white solid. LC-MS (M+H=366, obsd.=366).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-7c0037d4d31246c580d52055c237dbf3
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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