HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ol → 1-(3,4-Dihydro-2H-benzo[1,4]oxazin-7-yloxy)-5H-benzo[c][1,8]naphthyridin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ol | HCID 19386564 | — |
| Reactant | 1-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one | HCID 58168008 | — |
| Product | 1-(3,4-Dihydro-2H-benzo[1,4]oxazin-7-yloxy)-5H-benzo[c][1,8]naphthyridin-6-one | HCID 69810883 | 74% |
Reaction Steps
The title compound was synthesized according to the procedure described for the preparation of Example 182 using Compound 83 (250 mg, 1.08 mmol) and 3,4-dihydro-2H-benzo[1,4]oxazin-7-ol (328 mg, 2.17 mmol) to provide 218 (276 mg, 74% yield) as a tan solid. LC-MS (M+H=346, obsd.=346).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735584B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-0eaf0ac0f91646d68415d01ed20b488b |
| Source note | uspto-grants-2014_05 |