5-Chloro-1,3-benzodioxol-4-amine → HCID 58168085, compound

HRID 1029188Notes

Reaction equation

HRID 1029188 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[Cl:26][C:27]1[CH:35]=[CH:34][C:30]2[O:31][CH2:32][O:33][C:29]=2[C:28]=1[NH2:36]>>[Cl:26][C:27]1[CH:35]=[CH:34][C:30]2[O:31][CH2:32][O:33][C:29]=2[C:28]=1[NH:36][C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2

Participants

3

Reactant 2

HCID 113672535-Chloro-1,3-benzodioxol-4-amineHCID 58168205HCID 58168205, compound

Product 1

HCID 58168085HCID 58168085, compoundYield 6.5%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 212 using 222 (90 mg, 0.25 mmol) and 5-chloro-benzo[1,3]dioxol-4-ylamine (56 mg, 0.33 mmol) to provide 225 (8 mg, 6% yield) as a white solid. LC-MS (M+H=568, obsd.=568).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-45bb6be3939b4e218372a44dfce70240
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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