3-Benzyloxyaniline → HCID 58168222, compound

HRID 1029190Notes

Reaction equation

HRID 1029190 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[CH2:17]([O:24][C:25]1[CH:26]=[C:27]([NH2:31])[CH:28]=[CH:29][CH:30]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([O:24][C:25]1[CH:26]=[C:27]([NH:31][C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[C:4]2[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=2[C:6](=[O:12])[NH:7]3)[CH:28]=[CH:29][CH:30]=1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 928923-BenzyloxyanilineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168222HCID 58168222, compoundYield 71.5%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using 83 (100 mg, 0.43 mmol) and 3-benzyloxy-phenylamine (130 mg, 0.65 mmol) to provide 227 (121 mg, 71% yield) as a tan solid. LC-MS (M+H=394, obsd.=394).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-2027875eb2384067b5e56c8a9fe612ed
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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