HRID1029191

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21081527

1-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

C12H8FNO3

反应SMILES：O=c1[nH]c2nccc(Oc3ccc4c(c3)OCCN4)c2c2ccccc12

HCID69810883

未命名化合物

PRODUCTS

产物

反应SMILES：O=C(c1cccn(-c2ccc(F)cc2)c1=O)N1CCOc2cc(Oc3ccnc4[nH]c(=O)c5ccccc5c34)ccc21

HCID58167948

未命名化合物

收率 83%

PROCEDURE

实验过程

The title compound was synthesized according to the procedure described for the preparation of Example 181 using 218 (40 mg, 0.12 mmol) and 1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (41 mg, 0.17 mmol) to provide 228 (54 mg, 83% yield) as a tan solid. LC-MS (M+H=561, obsd.=561).

WORKUP

后处理

customThe title compound was synthesized

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-28f0465256a847eb9eaf9bce3f79166c
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08735584B2
来源说明: uspto-grants-2014_05

反应SMILES

[O:1]1[C:6]2[CH:7]=[C:8]([O:11][C:12]3[CH:21]=[CH:20][N:19]=[C:18]4[C:13]=3[C:14]3[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=3[C:16](=[O:22])[NH:17]4)[CH:9]=[CH:10][C:5]=2[NH:4][CH2:3][CH2:2]1.[F:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]2[CH:39]=[CH:38][CH:37]=[C:36]([C:40](O)=[O:41])[C:35]2=[O:43])=[CH:30][CH:29]=1>>[F:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]2[CH:39]=[CH:38][CH:37]=[C:36]([C:40]([N:4]3[C:5]4[CH:10]=[CH:9][C:8]([O:11][C:12]5[CH:21]=[CH:20][N:19]=[C:18]6[C:13]=5[C:14]5[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=5[C:16](=[O:22])[NH:17]6)=[CH:7][C:6]=4[O:1][CH2:2][CH2:3]3)=[O:41])[C:35]2=[O:43])=[CH:30][CH:29]=1