3-Aminobenzonitrile → HCID 58168071, compound

HRID 1029196Notes

Reaction equation

HRID 1029196 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:5]2[C:6](=[O:14])[NH:7][C:8]3[C:13]([C:4]=2[CH:3]=1)=[CH:12][CH:11]=[CH:10][N:9]=3.[NH2:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[C:21]#[N:22]>>[O:14]=[C:6]1[C:5]2[CH:15]=[CH:16][C:2]([NH:17][C:18]3[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=3)[C:21]#[N:22])=[CH:3][C:4]=2[C:13]2[C:8](=[N:9][CH:10]=[CH:11][CH:12]=2)[NH:7]1

Participants

3

Reactant 2

HCID 167023-AminobenzonitrileHCID 581682989-chloro-5H-benzo[c][1,8]naphthyridin-6-one

Product 1

HCID 58168071HCID 58168071, compoundYield 16%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 231 using 6 (50 mg, 0.22 mmol) and 3-aminobenzonitrile (38 mg, 0.33 mmol) to provide 233 (11 mg, 16% yield) as a white solid. LC-MS (M+H=313, obsd.=313).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-9551eab9e2084dcc82b6cc75c1e3cb73
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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